The staff adjusts to the new normal of the pandemic. Dr. Choi, Dr. Lanik and April fight on the front lines. Dr. Halstead and Hannah face a troubling reality. Dr. Charles tries to clear the air with his daughter following recent developments.

Goodwin announces a new ED Chief and the choice doesn't make everyone happy. Dr. Manning takes a stand for her patient and finds herself dealing with the repercussions. Dr. Charles tends to family affairs.

Dr. Charles and April team up to take on a mysterious patient in the ED. Dr. Halstead is forced to make a life-or-death decision for one of his trial patients. Dr. Marcel is confronted by his past when a former acquaintance is brought into the ED.

Dr. Marcel and Dr. Manning lay everything on the line to assist a sick woman. Dr. Halstead faces an uphill battle in getting participants involved in his clinical trial. Dr. Choi clashes with a patient who demands absolute perfection of himself.

Dr. Halstead finds continued success in his trial. Dr. Charles' daughter, Anna, receives life-changing news. Noah finds himself in a situation not even April can fix.

Dr. Choi helps a patient with chronic pain find a solution. Dr. Halstead considers a new path. Dr. Charles and Anna bond over a scary situation.

Will runs into trouble when one of his trial patients falls ill. His own stress and symptoms have Ethan struggling to get through the day.

Ethan hires an old Navy colleague to join him in the ED. A final custody hearing threatens to separate Charles and his daughter. Maggie must make a choice that will change Auggie's life.

As Maggie deals with her own trauma, she steps in to help a mother in need. Dean continues to stir the pot with more than one doctor. A patient comes to Med needing immediate treatment, but doesn't want it from them.

Crockett deals with a patient who ends up having more in common with him than he thinks. Will and Ethan clash over a pregnant patient with an irregular heartbeat.

Ethan teams up with an unexpected person to treat a famous tennis player who is afraid his career might be over. Goodwin's new protocols cause a stir.

Dean and Ethan respond to a scene that brings back some bad memories. When Carol's condition worsens, Natalie is willing to do whatever it takes to get her mom feeling better.

An auto accident sends Goodwin into a spiral as she tries to help a young boy and his mother. Natalie's secretive behavior begins to draw the attention of Dr. Marcel and Dr. Halstead.

Third-year med students begin their rotation in the ED and Maggie keeps a careful eye on one of them. Natalie, whose mom's health takes another decline, tries to cover up how she broke the rules to treat her.

Crockett worries he made a surgical error when a recent transplant patient comes in with complications. Carol is once again in distress. Will and Natalie must take action to right their wrong.

Carol receives a second chance at life when a new heart becomes available. Ethan and Dean find themselves in hot water with an old patient. Will faces the consequences of the stolen trial medication.

Will Halstead returns to Med to help Goodwin with a secret investigation. Archer and Charles deal with twins who insist on being identical inside and out. Stevie and Dylan treat a young patient with sickle cell anemia.

Vanessa and Archer disagree on how to handle the victim of a motorcycle accident. Dylan and Charles deal with a UNICEF negotiator with repressed trauma. Stevie and Will treat a high schooler with Addison's disease and a clingy mother.

Dylan and Will deal with a dishonest patient whose lupus is in remission. A wealthy donor makes inappropriate advances toward Stevie. Vanessa, Crockett and Charles try to convince a young woman to have life-saving surgery.

Charles helps Dylan with a longtime patient who was recently diagnosed with schizophrenia. Stevie, Maggie and Vanessa investigate the legitimacy of a patient’s cancer diagnosis. Crockett is caught off-guard. Will pitches a new medical technology.

Dylan and Charles treat patients suffering from Glass Child Syndrome and misdiagnosed ADHD. Crockett has to navigate hospital politics when he cares for the daughter of a transplant surgeon. Will and Stevie must lay egos aside to help save an elderly patient.

Stevie’s personal and professional worlds collide when her mother becomes her patient. Dylan’s history with the father of a patient interferes with his perception of a case. Crockett's allegiances are challenged when his patient's liver is a potential match for one of Dr. Blake's patients.

Crockett helps Dr. Blake replace a patient’s liver. Vanessa tries to prove herself. Will continues to pursue the truth about Cooper. Ethan gets closer to returning to life in the E.D.

Dylan's loyalty to Med and the police department is challenged when an old family friend and veteran cop exhibits concerning behavior. The annual random drug testing puts a doctor’s career in jeopardy. Ethan tries a risky old-school method on a patient. Will helps Stevie search for her mother.

The outcome of Will's investigation weighs heavily on his mind as he works with Dylan to save a 4-month-old patient. Stevie and Vanessa both struggle to keep their secrets. Crockett and Blake work with Abrams to save a patient in need of a liver transplant.

In the aftermath of the Vas-COM scandal, Goodwin clashes with the hospital’s new compliance officer. Crockett and Blake try to save a patient who has a son with severe autism. A patient’s son lies to his father about his diagnosis.

Crockett and Blake clash with Randall when a famous alcoholic football player needs a liver transplant. Dylan is reluctantly reunited with old friends when their son breaks his arm. Stevie and Charles work together when a patient falls ill after back-alley plastic surgery.

Will and Stevie get stuck in the middle of a marital face-off. Dr. Blake's entire surgical team mysteriously collapses during a liver transplant. Charles encourages Ethan to reconcile with his father.

Scott and Archer diagnose a pregnant woman with a serious infection. Maggie receives shocking news. Halstead and Charles question an elderly patient’s Alzheimer’s diagnosis. In an effort to help a patient, Marcel takes a risk.

Goodwin assigns Med’s new compliance officer to a patient with a long-hauler COVID condition. Maggie helps Halstead treat a patient who's been in an iron lung for 60 years.

Scott suspects his patient may be a drug dealer. Halstead must decide how to spend his whistleblower settlement. Charles and Taylor help a patient who believes she's infested with parasites. Marcel and Blake are paired with an arrogant surgeon.

Halstead helps a patient with long-haul COVID-19 symptoms. Taylor reflects on her dating life when she learns that a patient's daughter is having an arranged marriage.

Rival gangs bring their war to Med. Halstead and Charles work with a brain cancer patient who's refusing treatment. Tensions run high in the OR when a patient's transplanted uterus fails.

Archer and Asher clash over a patient with close ties to Goodwin. After a patient is shot during a home invasion, Scott and Marcel help with the investigation. Maggie and Halstead work to protect a patient who is in the country illegally.

Halstead and Asher work to save a surrogate's baby. Charles cares for a patient on a hunger strike. Choi and Archer help a patient with ties to Choi's late father. Scott and Maggie are stumped by a drunk patient who claims to be sober.

Scott helps the daughter of a mob boss. A grandmother comes to Med desperate to save her grandson. Choi struggles with some shocking news about his father.

Dylan and Ethan treat a patient shot during a drug raid. Charles and Vanessa work together to properly diagnose a motivational speaker. Will and Hannah must turn to Crockett for help with a patient who's pregnant.

Halstead and Asher clash over a patient in need of a kidney transplant. Marcel faces a tough decision when Blake is in surgery. Choi and Archer treat the son of Med's general counsel. Med's family grows.

In the aftermath of Halstead's apartment fire, Marcel, Choi and Archer work together to try to save the survivors. Charles and Med's new fellow, Cuevas, help a paranoid patient.

Supply chain disruptions dramatically impact Med, causing Marcel to clash with other doctors. Maggie reveals something to Ben. Choi and Archer help a patient with ALS.

Charles and Cuevas clash over the treatment of a paranoid patient. Choi treats a pregnant patient from Asher's past. Marcel and Taylor help a man who needs a risky neurosurgery.

When a subway train goes off the tracks, Marcel volunteers to help the victims. Taylor and Halstead must decide if they’re willing to risk their jobs to save a patient. Asher and Archer clash over a pregnant patient.

The effects of the supply chain shortages continue to impact the ED when Taylor's drug dealer reappears. One of the victims of the recent train crash needs a transplant.

Marcel adjusts to his newfound fame when he helps Halstead treat a local restaurant owner. Choi, Charles and Goodwin aid a new mother worried about hurting her baby. Maggie and Taylor clash with a patient eager to get back to work.

Med runs out of scrubs, forcing the staff to improvise. The life of Archer’s son is in danger. Marcel and Charles help a kidney transplant patient experiencing psychosis. Asher and Halstead grow closer.

Halstead and Marcel facilitate a trans-organ exchange. Asher and Cuevas help a sexual assault survivor. Choi and Archer treat a patient whose case could expose a fraudulent doctor.

Halstead relies on Marcel and Med's newly donated OR 2.0 to save his patient. Charles helps an elderly, confused patient who's mourning the loss of his high school sweetheart. As their wedding day approaches, Choi and April run into some roadblocks.

Charles and Cuevas help an elderly patient and her developmentally disabled grandson. Halstead treats a swimmer with a heart condition. Marcel considers using the OR 2.0 for surgery.

Marcel and Charles treat Lieu's gym buddy. Maggie and Halstead help a robbery-homicide suspect. Asher and Archer use Med's new opiate abuse AI program.

Goodwin, Maggie and Marcel help victims of a hit-and-run accident. Halstead struggles to diagnose a patient with seizures. Asher and Archer clash with Jack Dayton.

A brutal storm rocks Chicago. Halstead encourages Dr. Grace Song to go against her own findings for the benefit of their patient. Asher rushes to the hospital to help Archer's pregnant patient. Maggie's concern for Ben consumes her.

Goodwin and Charles clash as negotiations drag on between the administration and the custodial workers' union. Asher fights to keep a mother and her newborn baby together.

The hospital is in disarray when the janitors go on strike. Marcel treats a young girl injured on her family's farm. Charles and Cuevas' schizophrenic patient returns to Med.

Halstead and Cuevas struggle to diagnose a patient with a rare disorder. CFD and Med staff work to free a paranoid father trapped in the MRI suite. Tanaka-Reed gets an ego check.

A documentary crew visits Med to film Marcel and Abrams' groundbreaking surgery. Archer refuses to ask for help for his kidney issues despite the staff's unrelenting kindness.

Dr. Song launches her pilot program, giving the E.D. a technological facelift. Archer clashes with Charles on a patient faking paralysis. Archer helps a pregnant mother with a heart condition.

The fate of the hospital rests on the vote of an incapacitated board member. Archer helps a mother with a rare stem cell disease while Asher treats the woman's pregnant daughter. Charles encounters a schizophrenic patient with a hearing impairment.

Maggie clashes with Charles over a distrustful patient. Marcel and Halstead fight against Med's new policies. Asher and Archer pull surprising things out of their unsuspecting patients.

As Jack Dayton prepares to launch OR 2.0's IPO, Marcel and Grace search for data that may put a wrench in his plans. Charles helps a schizophrenic patient who is anxious about prom. Asher clashes with Abrams when his wife becomes her patient.

Shocking information threatens Jack Dayton's surgery and the future of OR 2.0. Archer goes rogue to save a patient in need. Maggie questions her future at Med.

When the E.D. is flooded with patients from a crash, the entire team is pulled in to help. Charles can't shake the feeling that he knows the new E.D. attending. Archer has second thoughts on the eve of his kidney transplant.

A woman from Archer's past returns and threatens his transplant surgery. Marcel clashes with Med's new eager first-year resident. Charles works to repair his relationship with Ripley.

Frustrated with an insurance company, Ahmad takes matters into her own hands, jeopardizing Med's negotiations and Marcel's first day on the board. Charles helps a woman's depressed husband. Asher's first date takes a surprising turn.

Goodwin is worried after an accident lands two people close to her in the E.D. Archer returns to Med and treats a man concerned about a family curse. Maggie and Ahmad help a patient on a cross-country road trip.

Goodwin recruits Charles to evaluate her ex-husband's memory. Archer treats one of Sean's peers from the rehab center. Asher treats a woman from a rural clinic whose miscarriage was improperly treated.

Maggie empathizes with a patient whose mother is afraid to consent to her son's risky surgery. Ripley treats someone from his past. Ahmad questions her instincts.

Ripley and Charles treat a patient with OCD. Asher and Archer encounter a woman with a foreign object lodged in her heart. Marcel clashes with the chief of oncology.

Archer, Asher and Charles encounter an expecting father who claims he's telepathic and receiving messages from his yet-to-be born son. Ahmad works to thaw out a frozen criminal.

Ripley and Charles treat members of a cult. Ahmad's suspension takes an unexpected toll on Marcel. Abrams' 5-month-old son lands in the E.D. under questionable circumstances.

Maggie's budding romance takes flight. After a woman's shocking suicide attempt, Charles searches for answers. Asher works to diagnose a patient who is new to the city and appears with mysterious symptoms.

Ripley struggles to keep Sully's diagnosis a secret when the latter's pregnant girlfriend comes to Med for help. Johnson works to earn a spot in Med's trauma fellowship. Charles and a medical student treat a bipolar artist.

An infection threatens Marcel's risky liver transplant. Maggie and Charles help a struggling burn unit nurse. Goodwin is forced to make a tough decision about Bert's future.

Ripley and Charles treat a high-risk prisoner who may have dementia. Archer and Sean clash when a resident from Margo's facility lands in the E.D. Marcel receives shocking news.

When a commuter ship capsizes, the ED finds itself under water as the staff struggles to treat the influx of new patients and deal with bold new employees taking charge.

Lenox continues to rankle Archer as the two tackle their new roles. Ripley faces possible suspension over what really happened to Pawel. Goodwin is forced to make layoffs.

Asher treats a woman whose undiagnosed condition threatens the lives of both her and her unborn child. Goodwin receives a chilling message while battling the hospital higher-ups.

A familiar face returns to the ED. Ripley and Charles treat a woman with a rare disorder. Frost suspects that his patient's father is lying about his daughter's condition.

Halloween chaos takes over the ED. Asher helps a pregnant woman with an autistic son. Charles clashes with Nurse Jackie on a psych case.

Chicago P.D. steps up Goodwin's security after she's threatened online by a former employee. Archer and Frost treat victims from a disciplinary camp injured during a rockslide. Maggie gets roped into delivering a high schooler's baby.

Ripley and Frost uncover shocking information that conflicts with their patient's DNR. Asher facilitates an unexpected reunion. The tension between Archer and Lenox comes to a head.

Goodwin's troubles persist. Charles clashes with his former resident over a depressed patient. Lenox and Ripley treat a car accident victim who recently reunited with his college sweetheart.

The team fights to save the life of one of their own. Frost and Abrams butt heads with their patient. Asher helps a religious young woman with an ectopic pregnancy.

An army of surgeons prepares to separate conjoined twins. Asher reconnects with someone from her past. Archer treats a tyrannical boss with a heart problem.

Following the subway tunnel collapse, Ruzek and Kidd treat injured passengers and track down the missing offender. Archer and Frost perform a life-saving amputation.

The crossover starts on Chicago Fire S13E11 In the Trenches (I). It continues on Chicago P.D. S12E11 In the Trenches (III).

Goodwin struggles with the psychological aftermath of her attack. Ripley treats a patient with helicopter parents. An ED staffer makes a mistake that may cost them their job.

Lenox's mentorship is put to the test. Asher helps a religious young woman with an ectopic pregnancy. Ripley's self-destructive behavior continues to escalate.

Gaffney gets a surprise visit from a National Accreditation Board of Hospitals representative. Asher and Naomi search for the cause of a young girl's infection. Lenox and Frost work together to save the victim of an accidental shooting.

Ripley struggles to rescue a woman and her daughter trapped in an abandoned well. An old friend from Frost's TV days shadows Maggie. Asher discovers an extremely rare condition in her patient's ultrasound.

When her former patient returns to Med, Goodwin learns that time doesn't heal all wounds. Frost and Charles treat a patient struggling with his sexuality. Lenox and Abrams work to save a woman who has been in a coma for 20 years.

Charles and Archer treat a heart transplant patient who believes his new heart doesn't want to be in his body. Lenox takes a personal day. Asher discovers a mass on a pregnant woman's ovary.

Asher makes a tough call to save a life. Frost and Ripley treat a young boy with a snake bite. Archer gives Naomi a patient to handle on her own on her last day in the E.D.

Maggie and Goodwin's friendship is tested as tensions rise during the nurses' union's negotiations with the hospital. Ripley and Archer treat a skateboarder struck by an emergency vehicle. Frost helps a young boy abandoned by his mother.

The hospital faces a staffing crisis as the nurses stage a sick-out. Archer and Frost bet on who can discharge their patients first. Charles' distrust of a patient complicates his treatment.

Maggie and Frost fight to get a pair of lungs for a young cystic fibrosis patient. Asher learns whether she can become a surrogate. Ripley and Morris treat a tech billionaire's daughter as she battles leukemia.

Goodwin is tasked with enforcing difficult cuts to hospital personnel. Charles' daughter is hospitalized after a car accident. A transplant patient makes a life-changing decision.