Crockett and Blake clash with Randall when a famous alcoholic football player needs a liver transplant. Dylan is reluctantly reunited with old friends when their son breaks his arm. Stevie and Charles work together when a patient falls ill after back-alley plastic surgery.

Will and Stevie get stuck in the middle of a marital face-off. Dr. Blake's entire surgical team mysteriously collapses during a liver transplant. Charles encourages Ethan to reconcile with his father.

Scott and Archer diagnose a pregnant woman with a serious infection. Maggie receives shocking news. Halstead and Charles question an elderly patient’s Alzheimer’s diagnosis. In an effort to help a patient, Marcel takes a risk.

Goodwin assigns Med’s new compliance officer to a patient with a long-hauler COVID condition. Maggie helps Halstead treat a patient who's been in an iron lung for 60 years.