An army of surgeons prepares to separate conjoined twins. Asher reconnects with someone from her past. Archer treats a tyrannical boss with a heart problem.

Ripley struggles to rescue a woman and her daughter trapped in an abandoned well. An old friend from Frost's TV days shadows Maggie. Asher discovers an extremely rare condition in her patient's ultrasound.

Asher makes a tough call to save a life. Frost and Ripley treat a young boy with a snake bite. Archer gives Naomi a patient to handle on her own on her last day in the E.D.

Maggie and Goodwin's friendship is tested as tensions rise during the nurses' union's negotiations with the hospital. Ripley and Archer treat a skateboarder struck by an emergency vehicle. Frost helps a young boy abandoned by his mother.

Goodwin is tasked with enforcing difficult cuts to hospital personnel. Charles' daughter is hospitalized after a car accident. A transplant patient makes a life-changing decision.