Brian risks his new FBI job when he disobeys orders to stay out of the investigation into a renowned journalist’s murder.

Brian offers to use NZT to capture the FBI's "Ten Most Wanted" criminals in two weeks, in exchange for Naz giving him his own personal work "headquarters" at the agency. Also, the secretive nature of Brian's new life working for the Bureau creates a rift between him and his father.

When a developer at the tech think tank Brian frequents is murdered, he and Rebecca interview the robotic version of the victim that she created before her death for clues to the killer's identity. Also, Brian screens agents for a position to join Mike and Ike as his third bodyguard.

Brian and Rebecca are placed under quarantine by the CDC after being exposed to an unknown substance after investigating a citywide blackout. Also, trust issues arise after Rebecca catches Brian using his secret stash of NZT.

When NZT floods the streets of New York City and threatens to become a national epidemic, the FBI partners with the DOJ in a city-wide manhunt to find the lab producing the drug. Also, Brian has trouble adjusting to his new reality when he lacks the resources to continue searching for Piper.