Supergirl continues to fight Nyxly for the remaining totems but after Nyxly kidnaps William, Supergirl realizes she needs to take a more proactive stance to keep National City safe. Meanwhile, Alex faces the biggest challenge of her life.

Supergirl is determined to keep everyone safe from Lex and Nyxly so she doubles down on patrol, especially as Alex and Kelly's bachelorette party is coming up. Alex is torn between duty and finally allowing herself the time to enjoy her new family. Brainy receives heartbreaking news, and William clashes with Andrea over her recent coverage of Lex.