Patterson and her puzzle-expert boyfriend, David, decode a tattoo clue that sends the team to the Centers for Disease Control (CDC). While at the CDC, the team discovers a hidden message on Jane's body that uncovers a plot that could have catastrophic global consequences. Meanwhile, Jane and Weller grow closer.

When an assassination leads the team to a dangerous app that allows criminals to track government vehicles, they have to work with the app's surprising creator to take it down. Jane and Weller attempt to keep their relationship professional. Zapata struggles with a moral issue.

One of Jane's tattoos sends the team to a remote location where they find themselves face to face with a dangerous criminal in a case that puts Jane and Weller's strained relationship to the test and threatens to expose Mayfair's secrets. Meanwhile, Patterson breaks the rules to solve a tattoo puzzle.

Jane and Weller go undercover as a world-class assassin couple to prevent deadly information from getting into the wrong hands. The intimate assignment draws them closer than ever. Meanwhile, David embarks on a solo mission to win Patterson back, and Carter clashes with Mayfair over how to handle a dangerous individual.

After an armored truck is robbed, the team discovers that the stolen goods are chemical weapons and they must race to thwart a terrorist plot. Meanwhile, Jane grapples with a confusing memory of Weller - while growing even closer to Oscar. Meanwhile Patterson receives a phone call from someone from her past.

After Patterson discovers a hidden message in the New York Times crossword, she embarks on a tattoo scavenger hunt that leads her into danger. Oscar finally tells Jane more about who she was, and Weller seeks his Dad's opinion about who kidnapped Taylor Shaw.

When Patterson's investigation into a tattoo results in a horrible incident, she tries to figure out what went wrong - but quickly realizes all is not as it seems.

Turn off your mind, relax and float down stream...it is not dying...it is not dying.