The FBI is locked down when criminal hackers infiltrate the building, trapping the team inside SIOC. As they fight their way out, the close quarters force Mayfair, Zapata, Reade, and Sarah to confront personal conflicts.

Nas and Weller navigate their new dynamic as co-leaders during the team's hunt for a museum gala assassin, who turns out turns out to be harboring a dark secret. Jane starts to see a softer side of her old organization.

Rich Dotcom returns to the FBI when he needs help with a pressing issue.

As the FBI copes with a tragedy, Weller finds himself at the center of a surprising event. Jane faces an uncertain future.

While Jane and Weller partner with a mysterious man from Jane's past to find a missing person, the team races to stop an arms deal.