Patterson and her puzzle-expert boyfriend, David, decode a tattoo clue that sends the team to the Centers for Disease Control (CDC). While at the CDC, the team discovers a hidden message on Jane's body that uncovers a plot that could have catastrophic global consequences. Meanwhile, Jane and Weller grow closer.

One of Jane's tattoos sends the team to a remote location where they find themselves face to face with a dangerous criminal in a case that puts Jane and Weller's strained relationship to the test and threatens to expose Mayfair's secrets. Meanwhile, Patterson breaks the rules to solve a tattoo puzzle.

In the thrilling mid-season finale the team goes after a group of sleeper spies that have just been activated and race to stop a slew of assassinations.

After a tip reveals there's a mole within the FBI's New York Office, the team must hunt for the operative while facing extreme scrutiny from Inspector Fischer. The team's deepest secrets threaten to be exposed, and everyone is a potential suspect - but some, especially Jane Doe have more to hide.

After a painting featuring one of Jane's tattoos is heisted from a gallery, the team discovers Jane is the real target. In order to protect her team, Jane goes AWOL.

In order to capture a dangerous international criminal, Jane and Weller are forced to collaborate with the only person he will meet: their former target, Rich DotCom. Jane must decide whether to risk hurting Weller by executing a morally questionable order from Oscar.

The FBI is locked down when criminal hackers infiltrate the building, trapping the team inside SIOC. As they fight their way out, the close quarters force Mayfair, Zapata, Reade, and Sarah to confront personal conflicts.

Weller and the team must race the clock to stop a series of escalating New York City bombings, while Jane is forced to go on an assassination mission to prove her loyalty... or suffer the consequences.

While Weller and Nas chase a fugitive whistleblower in Bulgaria, Jane goes on a Sandstorm mission with Roman. Reade and Zapata must deal with an urgent matter.

After Jane discovers that Sandstorm is gearing up for an imminent attack, she risks everything to send a secret SOS to her FBI team.

After a set of tattoos produces multiple leads, the team divides into unlikely pairings to chase down a deadly underworld courier.

Under investigation by an old rival, the team struggles to defend itself. Meanwhile, a tattoo leads them to a mysterious death at a foster home

The team finally cracks a member of Sandstorm, leading to a huge breakthrough in uncovering Phase Two.