When a gamma virus outbreak occurs in Chicago, Dr. Donald Blake transforms into the mighty Thor to force the Hulk to Chicago. Bruce has to work with Gargoyle, who released the virus, to find a cure.

Betty encounters the legendary monster, Wendigo. Bruce is unable to save her because Agent Jones and General Ross capture him. Even though he escapes, he is handcuffed to the General, and as much as they hate to admit it, they'll have to work together to save Betty.

Betty and Doc Samson have found a way to seperate Bruce from the Hulk. All they need now is to smuggle the Hulk into the Gamma Base lab where the Nutrient Bath is waiting.

Bruce and the Hulk are now two separate beings, but the Hulk escapes and goes on a destructive rampage. The Leader captures him and has his intellect placed into the Hulk's body, acquiring the power he's craved.

Equipped with exo-armor, Bruce battles the Incredible Hulk in a massive battle in the desert. When it's over, it's discovered they can't exist without each other and are dying. Their only hope is rejoin via the Nutrient Bath, but General Ross' interference will cause it to go horribly wrong.

The Nutrient Bath has left Rick Jones transformed into a rampaging teenage Hulk and Bruce turning into a Gray Hulk. Bruce now faces a charge of attempted murder and his lawyer is Jennifer Walters (aka She-Hulk). Meanwhile, The Leader has a plan to capture Rick Jones and suppress Bruce's mind within Gray Hulk.

She-Hulk is taking part in a Miami fashion show for charity, when The Leader and Gargoyle attack. It's up to She-Hulk, Betty and a group of models to stop them.

Bruce and She-Hulk search for the mythical valley of Anavrin in Tibet, where they believe Bruce can be cured once and for all.

Gray Hulk and She-Hulk have to work Agent Jones and S.H.I.E.L.D. to save the Sea Base's unstable Gamma Power Core.