A bounty hunter who happens to be Hornstock's former partner helps Rosewood and Villa track a murderer; Pippy receives an opportunity that could launch her music career; Villa attempts to reconnect with her mother.

Rosie insists on celebrating his and Villa's nine-and-a-half month anniversary as partners, which lands them in the middle of a case involving none other than Julius "Joo-Joo" Beeman, their confidential informant. But, this time, Joo-Joo is the prime suspect. As Rosie and Villa work to uncover the truth, even if it means putting Joo-Joo away for life, they discover a whole new side of him they never saw coming. Meanwhile, Villa's choice for her new home has Rosie worried about the new path she's on, Pippy and TMI struggle to balance old friends and family, and Hornstock has trouble reading signals from the new, badass, female chief of police.

When a patient of Erica Kincaid's dies on the table, Rosewood steps in to help solve what turns out to be the murder of an undercover ATF agent. But when Villa connects with a cold case detective, it turns out this case has more angles than they ever imagined.

A hostage situation erupts at the East Miami Police Department, and Rosewood, Villa and Slade are trapped on the inside. Rosewood forms a strong bond with their captor and must solve his biggest medical mystery to date in order to keep his team alive.

When a victim, presumed dead, wakes up on Rosie's autopsy table, the team is thrown into a world in which people go to great lengths to keep their secrets hidden. Both Rosie and Villa are forced to re-examine the meaning of family, and Rosie's search for a Magic City Lab investor leads him to a surprising candidate.