Amidst the glitz and glamour of Miami Fashion Week, there's a plot to kill one of the city's hottest new designers, who turns to Rosewood for help. As the case takes Rosewood and Villa from the catwalk to the perp walk, Rosewood learns of his shared past with the victim. When he enlists the aid of his best friend, Dr. Mike Boyce, Rosewood unintentionally gives Villa the jolt she needs to get back into the dating pool. Potential love also is in the air for Donna, who tries her hand at online dating. Meanwhile, Pippy and TMI find their romance on the skids when Pippy discovers TMI has kept an important secret from her.

Rosewood and Villa dive into the hip Miami art scene to catch a serial killer who is on the cusp of creating a "masterpiece." Meanwhile, an impending lawsuit against Rosewood threatens the lifeline of Magic City Lab, and Rosewood tries to protect Villa from his best friend, Mike.

Rosewood and Villa must follow a trail of clues left for Rosie, before another victim falls prey. As things heat up between Villa and Mike, Villa escapes by throwing herself deeper into the case, which inevitably pushes her closer to Rosewood. Meanwhile, Donna intervenes when Pippy decides to give TMI’s absentee mother a piece of her mind. Plus, the Chief position is Hornstock’s, if he is willing to pay a stiff price.