After meeting in a bar over too much tequila, Kim and Miles wake up handcuffed to Kim's bed frame and find that the key is missing. Mona, who is a lesbian, and her straight twin sister Dominique swap places and hook up with each other's lovers. Vanessa dresses Jamie in drag for a drama exercise, then Jamie uses the disguise to get to know Sabrina better.

Miles, still handcuffed to Kim, tries to convince her that they are meant for each other. Mona gives Dominique's boyfriend Jonathan oral sex tips while Dominque takes a shower with Mona's girlfriend, Joy. Jamie remains in drag to attend an all-girl slumber party, but his plan backfires when boys arrive and he has to play spin the bottle as a girl.

Russell, a multi-millionaire, surprises ex-girlfriend Cory by showing up at the Love Nest, where he offers Bryce money to leave Cory alone. After Milo sees Kitty kissing Dale, Kitty breaks up with Dale and tells him to take Terry to the Luau. Kitty gets together with Milo. "Double D" Denise tells the girls which boys cheated on them, and agrees to help the girls arrange a "pajama party" where the girls will get back at the guys.