Vanessa Helsing, a distant relative of the famous vampire hunter Abraham Van Helsing is resurrected, but soon realizes that the world was conquered by vampires. Tya is humanity's last hope to lead people to regain their lost.

The hospital's power source is damaged, jeopardizing the protective UV lights. Vanessa and Axel head into Seattle to scavenge parts, leaving the others to fight against the vampires amongst themselves.

Vanessa and Mohamad head into the vampire-controlled streets in search of Vanessa's daughter; Cynthia is found dead at the hospital, and Doc thinks her apparent suicide is actually a deliberate murder; Vanessa is captured by vampires.

Vanessa, now in the clutches of Julius and his vampire brood, is forced to demonstrate her powers; the refugees discover a serial killer among the residents, and plot to wrestle control from Axel.

Vanessa and Susan are pursued through the sewers by mutated feral vampires and arrive back at the safety of the hospital only to find the aftermath of a hostile takeover. Vanessa hatches a plan to take it back by force.

Vanessa and Axel lead the others in the hospital's last stand against a siege by Julius and his vampire soldiers. Later when Dmitri's vampire 'Death Squad' arrives, it looks like civil war is brewing among the two vampire factions.

Axel leads the surviving members of their group towards his old military base for shelter but finds it abandoned and in disrepair. With vampires closing in all around them, Axel decides they need a safer refuge and decides to go underground. Separated from Vanessa and the group, Mohamad tries to catch up while navigating hostile territory.

The group is trapped inside an underground lab for military experiments, and Vanessa discovers that Axel has been hiding a secret about her past; Mohamad befriends a girl who doesn't fear vampires; Rebecca makes a calculated play.

Still reeling from the dire events of 'The Farm', Vanessa and the group find refuge among a band of humans who have bargained with vampires for peace. Their leader, however, appears to be hiding a terrible secret. Meanwhile, the true serial killer among Vanessa's group is finally revealed.

Vanessa and the group take shelter in Susan's family farm, where drastic action is taken against Sam; Rebecca's latest experiment to create Daywalkers fails, and Dmitri's patience grows thin.

While on the road to a vampire-controlled camp, Vanessa and Mohamad find themselves in a dangerous game of cat-and-mouse against Sam. Sheema discovers a secret that can bring down the ghetto-cell of the Resistance, while Julius takes a clandestine meeting with Dmitri. Ultimately, Vanessa and Mohamad walk into a trap that places one of them in great peril.

Vanessa makes a horrific decision to save her daughter; Axel and a former ally struggle to survive in the wild; a group of juvenile delinquents come face to face with a sadistic vampire.

Vanessa encounters a group of vampires whose gruesome methods bring savagery to a new level; Sam continues his game with the juvenile delinquents and that has deadly consequences.

Vanessa faces off against Sam in a bloody showdown; Dmitri hears news that sends him on a warpath after Vanessa; Flesh, Mohamad and Lucky take desperate steps to save their lives.

Vanessa faces off with Dmitri; Axel fights against becoming a full-fledged vampire; Sam tracks Mohamad, Flesh and Lucky; Scab tries to enlist a fierce group of vampires to join Dmitri.

Sam and Mohamad's shared past comes back to haunt them in more ways than one; at a secluded campsite in the woods, friendships are put through a baptism by fire.

Vanessa is once again resurrected and must confront her family's legacy; Axel, Scarlett and the others fend off Blak Tek's forces, who hope to add Scarlett to their list of lab rats.

Sam comes to realize his dark destiny and tries to groom Mohamad to be a worthy partner. Scab and Ivory are bestowed Daywalker powers and return home to find the Sisterhood in ruins.

Sam approaches his destiny. Mohamad tries to escape his servitude and imprisonment. Axel leads the San Francisco refugees to Denver. Ivory and Scab assume control of the Daywalker horde.

Vanessa, trapped in an abandoned slaughterhouse, wrestles between the light and dark sides of her own self before she can move forward on her path to find the Final Elder.

In his hometown, Axel fights both his tragic past and a vicious pack of Daywalkers. Sam can't find Mohamad, and takes his anger out on Chad and Mike.

Vanessa and Sam face off to find the Last Elder, with Scarlett, Axel and Mohamad caught in the crossfire.

With the amulet in hand, Vanessa and Lily escape from Elder Sam and return to the real world.

After an epic battle, Axel reconciles with Vanessa and comes to terms with the death of Scarlett.

Sam and the Brides arrive at Fort Collins, where Hansen reveals a secret for raising the Dark One.

Three generations of Van Helsings come together before a showdown with Elder Sam and the Oracle.

Vanessa wills Axel into The Dark Realm where they both discover secrets of their past that may help them in the future.