Paralyzed in a car accident, Riley O'Reilly receives a mansion as settlement. Riley spends all of his settlement money on parties and beer, and his differently abled friends leave because he's always drunk. Riley comes to them to entice them to live with him, on the condition that he gives up drinking.

Spalding gets all the quads jobs so they can get their self esteem back. When they're all fired, they start renting out their mansion to people who want to have parties. Things turn out pretty wrong when the Hells Angels end up at the Bromberg's house, par Blazer's bad writing skills.

Desperate to climb the social ladder, Liz Bromberg tries to exploit the magnificent severed by holding a Telethon for ""unfortunate gimps"".

Reilly is determined to prove a suave visitor is a fraud before the Latin Love Quad steals Franny's heart.

Reilly wins a hi-tech wheelchair. 'GAL', at a Handi-Capable Home Show. GAL is the ultimate gadget, until the machine takes over Reilly's life.

Suddenly unable to perform in the bedroom, Reilly does a deal with the devil; erections-on-demand for his soul.

Reilly buys a trained monkey to be his new hands and feet, prompting his pals to fill the house with more hairy assistants.

The unexpected visit of Fontaines' son sets Franny's biological clock ticking, prompting Reilly to experiment with various methods of sterilization.

The promise of money and drugs lures Reilly and friends to be subjects for medical experiments. The results are brilliant - untill the side effects kick in.

An attractive 'thalidomide', Randy, moves into Maimed Manor. Reilly is swept up in the local election, running for City Council against Liz Bromberg.

Spalding blackmails Reilly into helping him win the heart of an old flame whilst Griz's rough 'n' tumble alcoholic sister tries to win Spalding.

Spalding's parents come to visit, but Spalding thinks they don't know he's gay.

Reilly's battle with sobriety is challenged over Christmas, especially with a barkeeper for a friend.

When Lefty fasions an omlette that looks like the Virgin Mary, Reily displays it as a get-rich-quick scheme. To sell his newfound ""religious beliefs"", Reily becomes a minister, drawing people from all over for his sermons and to see the omlette. His only opposition is Sister Butch, who tries to stop him at any means nessacery.

Riley forgets Frannie's birthday, and she meets a lesbian at a cafe. Riley becomes concerned after Frannie spends more time with the lesbian then with him. In the end, Riley has to win her back.

Fontaine re-discovers his power over women's sexual needs.

Blazer meets a girl at a rave, and when she's found dead the next morning, everyone thinks Blazer killed her! It's up to the quads - with a little help from their lawyer - to clear Blazer's name.

Riley dresses up as Mrs. Venables to assure that the pension checks keep coming, but when her living quarters are ""undesirable"", she is taken to a nursing home and gets stoned, and Spalding, Lefty, Blazer, Griz and Fontaine have to break him out.

Riley's uncle Bob dies, and he leaves Riley a bunch of money. At the same time, the St. Germaine rubies are stolen, and all evidence points to Riley. The Quads have 24 hours to clear Riley's name and find the real criminal. The real criminal is the one you wouldn't expect..

Griz discovers his talent - he can play the piano - but this makes Lefty jealous, because he feels that he is the only one with any talent.

Riley needs a kidney transplant.

Blazer gets hit by the gambling bug once more, and he loses the house and Frannie! It's up to Frannie to convice the mysterious Debt Collecter to give back her and the house, with a little help from some feminist books.

The gang (even Franny) go on a reality TV show called CRIPPLE CHALLENGE, but the only reason Franny's on the show is because of her breasts.

Riley tries to help big-time rock star Flem Fleming become sober, but there's one problem: Flem can't stop drinking, and he even convinces Riley to drink, too!

Lefty is cast in a horror movie, but he wants to act theatre-style.

This episode centers on Riley trying to win a type of Special Olympics so he can become rich with a sponsership deal.