In the river region of The Gambia in 1750, Omoro Kinte and his wife, Binta, give birth to a son, Kunta. Kunta is kidnapped in 1767 and sold to British slave traders. After arriving in Maryland, Virginia planter John Waller purchases Kunta.

Redcoats attempt to persuade slaves to run away and join the English army. Kunta escapes but slave catchers apprehend him and amputate half of his foot to ensure he never runs off again. John Waller sells Kunta to his younger brother, William.