Riggs and Murtaugh look into the murder of one of L.A.'s fashion expeditors and discover an underground DEA operation. With Trish and the kids away, Murtaugh goes on a 'bender'. Riggs has all-too-real dreams of Miranda.

Riggs makes a shocking discovery about Miranda’s death that leads him back to the cartel in a frantic search for answers. His wild desperation leaves Murtaugh torn between his commitment to his partner and his commitment to his family.

Murtaugh follows Riggs down to Mexico, where he plans to avenge his wife's death and finish off Tito Flores once and for all. Once back in the States, they have a few people to answer to during the ongoing investigation around Flores, including Murtaugh's family. Avery is questioned by Internal Affairs about the integrity of his department.

Riggs and Murtaugh are drawn into a fatal world of conspiracy theories. Riggs' relationship with Molly evolves. Murtaugh and Trish attempt to get Harper into a fancy pre-school.

Murtaugh and Riggs search for the culprit of a local jewelry heist. Murtaugh gets called 'grandpa' by another parent while at the playground with Harper, sending him into a tizzy. Riggs deals with withdrawal from drinking.

Cole juggles the realities of his job and his duty to be a good parent, as he and Murtaugh work together to bust a gang running a lottery scam. Murtaugh gets ready to celebrate his 30th anniversary with the LAPD and receives a surprise visit from his competitive father-in-law.

Murtaugh takes a family vacation, but is pulled back into work when he witnesses an alleged abduction. Cole is left to investigate a murder himself, but the two cases begin to intersect. Meanwhile, Erica's mother, Senator Malick, comes to town and stirs things up between Erica, Cole and the case at hand.