After investigating the murder of a millennial 'designer drug' dealer, Riggs and Murtaugh find themselves in a violent turf war between a new generation of drug dealers and a Koreatown gang. Murtaugh finds some comfort in a temporary new partner. Trish attempts to set up Riggs with her co-worker.

Riggs and Murtaugh team up again with Palmer, and together they gain inside knowledge of dangerous new cartel operations. As Riggs’ attachment to Palmer deepens, so do his impulsive actions, further worrying Avery and Delgado. Trish explores the potential of an amazing new career opportunity.

A doctor is found dead in the pool of a wellness clinic. Riggs suspects a drug angle and asks Agent Palmer for help.

Riggs and Murtaugh are thrown into the world of counterfeit money. When a group of teenagers inadvertently gets involved, it strikes a chord with Murtaugh, who is dealing with his own issues regarding his son. Riggs decides to pay a visit to someone from his past.

On Murtaugh's first day on the job as interim captain, the wife of a popular businessman is abducted and the squad finds a connection in the case to Rigg's father. Riggs is left to grapple with his family and work.

New partners Murtaugh and Cole attempt to find a steady rhythm as they work to solve the murder of a finance executive. Cole navigates his role with his ex- and his daughter. Avery grapples with the outcome of his campaign for city council.

While Cole gets into the holiday spirit for his first Christmas with Maya, Murtaugh hopes he can convince RJ to come back home from Costa Rica for the holidays. Cole and Murtaugh are saddled with a complicated burglary and home invasion case. Avery's holidays are a bit blue. Bailey is still trying to figure out her new partner.

Against Murtaugh's advice, Cole reaches out to Tom Barnes to help with a case that hits close to home, putting Murtaugh and Cole's partnership to the test. Meanwhile, Trish prepares to announce her campaign for District Attorney.