Riggs and Murtaugh are forced to work with DEA agent Karen Palmer—again— to protect Leo Getz, an ambulance-chasing attorney who was linked to the Cartel. As the three delve further into the case, they begin to realize that Leo may not be the only one with a target on his back. Riggs begins to view Agent Palmer in a new light. Murtaugh is left worried after Trish makes a spontaneous decision.

When Riggs and Murtaugh attend Leo Getz's surprise wedding, they end up investigating a missing person. Riggs comes face to face with someone from his past. Murtaugh receives news that might change his life forever.

On Murtaugh's first day on the job as interim captain, the wife of a popular businessman is abducted and the squad finds a connection in the case to Rigg's father. Riggs is left to grapple with his family and work.

Former international CIA operative, Wesley Cole returns home and assumes duty as a police officer with the LAPD. Cole will find himself navigating a new partnership with Murtaugh, as he adjusts to life in Los Angeles. Avery continues his campaign for city council.

Cole reflects upon his time working for the CIA, as a person from the past makes a startling reappearance. Murtaugh struggles with his own mistakes, after a murder raises questions about a suspect he put away years prior. Leo Getz returns as the attorney on the case and tries to convince Trish to join his team.

When Cole is investigated by the FBI, Murtaugh is forced to question his loyalty to his own partner. Meanwhile, Cole works a case that puts Natalie's fiancé, Andrew, into the crosshairs right before their wedding day.