Cole confronts his past when his former mentor delivers alarming news, as he and Murtaugh investigate a robbery of safe deposit boxes. Murtaugh clashes with Trish's new client and enlists Bailey's help to investigate her.

Murtaugh turns to Cole's former mentor for help on a high-stakes cartel case. Murtaugh and Trish meet Natalie and Maya for the first time. Tensions mount between Bailey and 'The Gute' as the new partners begin to work together.

Against Murtaugh's advice, Cole reaches out to Tom Barnes to help with a case that hits close to home, putting Murtaugh and Cole's partnership to the test. Meanwhile, Trish prepares to announce her campaign for District Attorney.

When Cole is investigated by the FBI, Murtaugh is forced to question his loyalty to his own partner. Meanwhile, Cole works a case that puts Natalie's fiancé, Andrew, into the crosshairs right before their wedding day.