Cole confronts his past when his former mentor delivers alarming news, as he and Murtaugh investigate a robbery of safe deposit boxes. Murtaugh clashes with Trish's new client and enlists Bailey's help to investigate her.

Murtaugh turns to Cole's former mentor for help on a high-stakes cartel case. Murtaugh and Trish meet Natalie and Maya for the first time. Tensions mount between Bailey and 'The Gute' as the new partners begin to work together.

While Cole gets into the holiday spirit for his first Christmas with Maya, Murtaugh hopes he can convince RJ to come back home from Costa Rica for the holidays. Cole and Murtaugh are saddled with a complicated burglary and home invasion case. Avery's holidays are a bit blue. Bailey is still trying to figure out her new partner.

Murtaugh and Cole investigate the murder of an underground MMA fighter when Murtaugh realizes his fighting moves aren't as sharp as they once were. Meanwhile, Trish is unfulfilled by her practice and considers running for a public office. Also, Cole and Erica try to keep things casual and uncomplicated but their plan backfires when Maya reacts to her family changes in a negative way.

When Cole and Murtaugh investigate a case involving a father and daughter crossing the Mexican border, they end up uncovering a major issue with California Boarder Patrol. Meanwhile, Trish prepares her campaign for D.A. and must face parts of her past, before they find their way into the media spotlight. Cole also confronts his past when he experiences flashbacks as a result of an injury.

Against Murtaugh's advice, Cole reaches out to Tom Barnes to help with a case that hits close to home, putting Murtaugh and Cole's partnership to the test. Meanwhile, Trish prepares to announce her campaign for District Attorney.

When Cole is investigated by the FBI, Murtaugh is forced to question his loyalty to his own partner. Meanwhile, Cole works a case that puts Natalie's fiancé, Andrew, into the crosshairs right before their wedding day.