When MacGyver comes face to face with Murdoc, an international assassin hired to kill him, Mac must defend both himself and Bozer, armed with only a corkscrew and paper towel rolls. Also, Bozer feels completely betrayed when he finally learns Mac's true identity.

Using a screwdriver and bug spray, MacGyver must find the U.S. government mole who is leaking classified intel to the organization that is trying to take down The Phoenix Foundation. Also, Sarah returns to help with the mission, and Nikki reappears, but Mac can’t tell which side she’s on.

When the team intercepts a terror group’s message meant for Murdoc, Mac poses as the psychopath to save the intended target and find out why they want Murdoc to assassinate him.

Murdoc moves forward with his plans for revenge against MacGyver by recruiting his recently released former cellmate to infiltrate the Phoenix Complex as a “lab technician” and kill every agent inside.

When Murdoc drugs and kidnaps MacGyver, Mac uses a needle and his teeth to escape and join the team to save Murdoc’s next victim.

The LAPD interrupts the team’s Christmas celebration to arrest Mac for terrorism when they find a body in a building destroyed by a bomb Mac built.

After one of Murdoc's go-to assassins agrees to hand over Murdoc to MacGyver in exchange for $10 million, the team finds itself protecting Murdoc from his former mentor, Nicholas Helman, who wants him dead. Also, Jack realizes he may still have feelings for Riley's mother, Diane.

Three months after quitting the Phoenix Foundation and moving to Nigeria, Mac puts aside his differences with his father and returns when he hears Jack is the target of a murderous dictator he double-crossed.

Murdoc abducts MacGyver’s girlfriend, Nasha, to force Mac to help him rescue his son, Cassian, from a kidnapper. Also, a dangerous individual from Murdoc’s personal life shows up, giving Mac a glimpse into the villain’s past.

MacGyver and the team set off on a dangerous capture operation after an Irish military intelligence officer approaches them claiming to know the whereabouts of “The Ghost,” a lethal bomb maker whom Mac has been hunting for years.

When Nicholas Helman resurfaces to carry out a killing spree, the Phoenix is forced to get help from the one person who knows him best… his protégé, Murdoc.

While on a mission to hunt down a Codex lead, Mac and the team discover Murdoc hacked their comms and has recorded them for months. Now, Mac and the team must stop Murdoc, who is working with Andrews, as they plot to kill thousands and reveal each Phoenix member’s most-guarded secrets.