Mac and Jack attempt to rescue a billionaire’s son after he is kidnapped by a former Navy SEAL who uses an EMP weapon to cut off power and communication lines to the Shanghai skyscraper where the boy lives.

When MacGyver takes Riley and Bozer into the wilderness for a weekend of survival training, things take a turn when they run into a violent group of criminals who are searching the rugged backcountry for a lost crate of money. Also, Jack and Matty go on a road trip to place Matty’s ex-husband and his family in witness protection.

The secret experimental cancer treatment Mac’s developing with a friend is discovered when culprits ransack their lab, kidnap Mac’s partner and plan to use the research to create a powerful new nerve agent.

Mac and Desi travel with Bozer to his childhood home when his aunt dies in a tragic accident, however, they soon discover she may have been murdered for trying to expose the city’s contaminated water supply. Also, Riley, Matty and Russ continue to follow leads on their nano-trackers investigation.