British Museum curator Lady Alex Lindo-Parker jets off to the Amazon in search of Victorian explorer Percy Fawcett's lost camp. A series of mishaps sees her joined by maverick American adventurer Hooten and they stumble upon El Dorado.

Alex puts her wedding in jeopardy as she follows Hooten to an idyllic Caribbean island, searching for Captain Henry Morgan's buried pirate treasure. With half a map each and other hunters on their tail, this larger-than-life expedition threatens to derail the biggest day in Lady Alex's life.