H.G. and Jane find themselves stranded on the Island of Doctor Monroe. Unaware that they are an instrumental part of the doctor's research, H.G. and Jane fight for their lives—along with Dr. John Stevenson—but in the end, not everyone will get out alive.

An unwilling participant of Dr. Monroe's experiments, H.G. feels himself changing. Now on a more level playing field and finally able to take on his friend and adversary, John Stevenson, H.G. and Jane race to escape the Island of Dr. Monroe.