Selepas mengalami tragedi peribadi, Bryan Mills memulakan misi penuh dendam kesumat untuk menggulingkan bos kartel yang kejam. Sementara itu, pasukan perisikan rahsia A.S. diketuai oleh Christina Hart merekrut Bryan untuk menjadi seorang operatif.

Bryan gets his first chance in the field but the mission goes bust, resulting in a tragic death. The team uncovers a group of government officials skimming off of refugee funds, which also leads Christina to reconnect with a long lost love. Meanwhile, Asha shows up unexpectedly at Bryan's doorstep.

Bryan and team search for a suspected terrorist who has been taken, leading them to uncover a deeper plot within their own government. Christina receives troubling news and turns to Harry for support. Asha expresses her concern over Bryan's fixation with Mejia.

Riley's insistence to uncover the truth behind a fatal drug given to war vets results in her asset's child being taken. Bryan defies orders to rescue the girl and uncover the truth. When a break-in at Asha's apartment leaves her shaken, a new neighbor is there to calm her nerves.

Christina mengarahkan pengambilan semula dokumen sensitif di Zurich yang diperlukan untuk mencegah bencana ekonomi dan politik.

The ODNI is asked to facilitate the defection of a Russian FSB agent, but the agent's pregnant girlfriend throws a curve in the team's plans. Meanwhile, Christina goes off the books to reveal a mole in the CIA, and John's attempt to resolve his brother's problem with a local gang results in a spiritual crisis.

During the team's efforts to thwart a Mejia weapons operation, Bryan is taken. As he relies on his ODNI training to survive, the team attempts a daring rescue. Meanwhile, Bryan and Asha take their relationship to the next level.

A Mossad agent from Christina's past asks for her help and protection. First, they need to know who is trying to kill Leah, then the "why" becomes rather obvious.

The spouse of an FBI agent is kidnapped. Bryan wants nothing left to chance when Mexico demands the return of Mejia. Asha learns the identify of her friendly neighbor.

Ketika FBI mengancam untuk memecat Christina, Bryan dan John mengetuai misi untuk menghalang rakan-rakan Mejia sebelum mereka menyeberangi sempadan.