An unlikely party comes to the aid of the administration as it seeks to discover the party responsible for nuclear testing in the Indian Ocean; Will is unhappy, but his boss doesn't seem to mind, when a request to beef up the Vice President's issue profile results in Toby's handing him boring, low-level minutae; Josh dismisses a NASA proposal for a manned Mars mission until an agency staffer shows him the error of his ways; a conservative talk show host makes a pathetic attempt to bait C.J. into appearing on his show.

As they remain at Donna's bedside while she recuperates from surgery to remove a pulmonary embolism, Colin questions Josh about his personal relationship with Donna. When Bartlet and Leo clash over the appropriate response to the Gaza attack, Kate makes the case for a summit meeting, and provides Bartlet with the hook he needs to get the Israelis and Palestinians to sit down together at Camp David.

Bartlet orders a strike on the terrorist training camp as he and his staff broker a peace settlement between the Israelis and the Palestinians, but Bartlet and Leo realize that their differences over the peace settlement are irreconcilable, warranting a change in Leo's responsibilities. Having returned from Germany, Josh expresses concern about Leo's well-being, and his observations turn out to be well founded.

Leo is rushed into bypass surgery after suffering a massive heart attack; as Toby and Josh scramble chaotically to get votes after Haffley demands Democratic support for a tax cut in exchange for ratification of the peace plan, it becomes quickly apparent that Jed must overcome his reluctance to name a new chief of staff; C.J. works with the State Department on getting U.N. and NATO approval of the peace accord; Charlie drags his feet about completing some minor graduation requirements because he's reluctant to keep his promise that he'll resign as Jed's body man to seek a better position once he has his degree; Donna returns to work; C.J. gets on Josh's case about his unhealthy diet.