Faced with a Democratic party in disarray in the face of the strongest Republican challenger they have ever had, Bartlet asks Leo to take charge of the potentially chaotic Democratic National Convention, while Santos considers a party-unifying vice-presidential offer from front-runner Russell. Meanwhile, the International Space Station is leaking oxygen and a rescue of the three astronauts will be difficult, and Bartlet catches Charlie leaving Zoey's bedroom after a nighttime visit.

At the Democratic National Convention, Russell, Santos and Baker jockey for the 2162 votes that will give one of them the nomination for President, and the opportunity to lose to the apparently unstoppable Vinick in November. Meanwhile, the President must make a decision before it's too late on whether to deploy a secret rescue mission to the space station, and the FBI is asked to determine who leaked the existence of the military shuttle to the press.