It's wedding day for Bree and Orson but things don't go quite as planned. Meanwhile, the body of a dead woman believed to be Orson's ex-wife is recovered, which interrupts the reception. Susan goes on a date with Ian, but trouble ensues when his in-laws show up at the restaurant. When Nora breaks up with her boyfriend, Lynette decide to hook up Nora with someone. Edie lets her 18-year-old nephew Austin come live with her for some time. Lastly, Xiao-Mei goes into labor.

It is a holiday weekend on Wisteria Lane. Bree and Orson are going on their honeymoon, while Gabrielle and Lynette are going a spa vacation and Tom is going on a camping trip with the kids. Meanwhile Susan is going on a quiet romantic getaway with Ian, not sure if she's cheating on Mike. However, things don't go as planned.

The divorce between Gabrielle and Carlos reaches new levels of bitterness. Susan is determined to jog Mike's memory, and realizes Edie has been posing as his girlfriend since he woke up. Tom decides that his dream is to open a pizza parlor, and Lynette is not delighted. Bree tries to break up Danielle and her history teacher, who's been having an affair with her. Meanwhile, Mike's phone number is discovered on a dead woman's body.

Everyone's lives on Wisteria Lane are forever changed when Carolyn Bigsby holds shoppers hostage at a local supermarket. Meanwhile, Gabrielle and Carlos finish dividing their assets: Gabrielle gets the house, and Carlos gets everything in it. Susan is preparing to go to Paris with Ian.

Lynette returns home from the hospital. Gabrielle decides to get back into modeling and travels to New York. Susan comes home to find Austin and Julie making out on her couch. Bree meets her antagonistic mother-in-law Gloria, with whom Orson is in a quarrel. Detective Ridley has Mike's house searched.

The residents of Wisteria Lane celebrate their annual holiday block party. Meanwhile, Gabrielle sets her eyes on a father of a girl she's coaching. Mike is arrested for Monique's murder. Thanks to Lynette, mothers of the neighborhood arrange a protest against Art. This causes his sister a heart attack. And Susan has to cook dinner for Ian's parents.

Tom and Lynette try to make Kayla feel like a part of the family. Alma Hodge decides to pay Orson and Bree a visit. Susan visits Mike in jail to tell him about the lawyer Ian got him. Gabrielle accuses Carlos of trying to sabotage her relationship with Bill. Bree organizes a dinner party to show Susan that Alma is alive.

Bree isn't happy Alma has moved to Wisteria Lane. Gabrielle's secret admirer is revealed. The new Scavo Pizzeria faces an uncertain future. Julie and Austin go to Edie about giving them parental consent to buy birth control pills.

Ian proposes to Susan. The Scavo pizzeria prepares for its grand opening. Mike visits a hypnotherapist in hopes of remembering Monique. Gabrielle's romantically interested in a lawyer, but he's working for Zach who wants her for himself. Bree is hospitalized after a fall, after being tricked to climb on a ladder to retrieve Monique's teeth.

All of Wisteria Lane gathers at Pizzeria Scavo for the grand opening event, while one resident meets an untimely fate and another accepts a marriage proposal.

Edie gets an unexpected visit from her son. An unexpected pregnancy causes complications. Victor Lang, a man in his 40s running for mayor of Fairview, introduces himself for Gabrielle. The deceased Rex Van De Kamp narrates.