Lynette feels her mother (guest star Polly Bergen as Stella) is marrying Frank (guest star Larry Hagman), an abrasive and obnoxious man, for all the wrong reasons, and thus tries to talk her out of it. Meanwhile, Carlos becomes concerned when he learns about Gabrielle's obsession with her doll, and Bob and Lee hire a non-maternal Renee to decorate their newly adopted girl's bedroom. Bree runs into Keith's ex-girlfriend (guest star Rochelle Aytes as Amber) and learns some shocking news about his past, and Susan tries to befriend a curmudgeonly man (guest star Gregory Itzin as Dick) who has given up on ever finding a kidney donor. In the meantime, Paul appears to have some plans for Beth (guest star Emily Bergl), as he books a trip for the two of them to a remote cabin in the woods.

Susan vows to get the most out of life when she learns that her dialysis isn't working and that, unless she receives a kidney transplant soon, she will die. Meanwhile, jealous of Lee and Bob's adopted daughter's routine for an upcoming school talent show, Gaby pressures Juanita to come up with a number that will outshine everyone; Bree makes it her mission to find a kidney donor for Susan; Lynette puts a plan into action to discourage a clearly non-maternal Renee from adopting a baby; and Beth Young struggles to figure out what to do with her life after Paul kicks her out of the house.