The ultimate consequences of domestic drug abuse become much clearer when Kilmer and the team discover a Vietnam veteran and DEA Agent who are dealing and using crystal meth from a small, local lab.

When a trio of young renegades sets out for Las Vegas carrying a highly communicable and deadly virus, Kilmer's team risks exposure to the outbreak to stop them from reaching their destination.

Kilmer and his team search for a domestic terrorist bomber who is targeting several large universities. But when Mo's lifelong friend, Amir, is named as a suspect and his career is placed in jeopardy, Mo is forced to question his own choices, as well as the viability of the Patriot Act.

When a crazed sniper goes on a killing spree in San Diego, the Threat Matrix team works with the FBI to stop the surprisingly young, troubled shooter.

Atkins is reunited with a Russian agent and an American double agent from his past when the team attempts to prevent poisoned money from reaching wide circulation.

Mo plays the roll of double agent in order to apprehend a small arms dealer who is moving missiles on to U.S. soil. Meanwhile, Atkins' trust is betrayed by a Senator holding court during an election year.

A bank hold-up in Mexico forces the team and the ambassador of Mexico to work together when secret alliances create a deadly situation that puts Frankie's life in real peril.

One of the Threat Matrix team is killed in an attempt to prevent the North Korean Prime Minister's daughter from being kidnapped.