All is not well at the Zoo-niverse. Animals are disappearing one by one. Things go from bad to worse when Joey Moose, one of the zookeepers, goes missing. When Mrs Gideon reports that her python is also on the missing list, Howard is determined to save the day. Howard and Vince stumble across Dixon Bainbridge's secret laboratory and the terrible truth behind his ‘experiments' comes to light.

Bollo, the eldest and most respected gorilla at the Zoo-niverse is gravely ill. Bob Fossil persuades Howard to dress in an ape suit, replacing Bollo, so that he can continue accepting sponsorship money for the gorilla. Everything's going smoothly until the Grim Reaper arrives and mistakenly takes Howard to Ape Hell instead. Vince sets off to rescue Howard and they run into trouble when they encounter the Ape of Death who is plagued with problem hair.

Vince is convinced that The Human League invented music. According to Vince, Howard's past career as a jazz trumpeter does not measure up. When Vince is offered a chance to join a new band, ‘Kraftwork Orange' with Johnny Two Hats and the Electro Girls, he's intent on leaving everything behind, including Howard.