The team at St. Bonaventure needs to quickly discover the truth behind a young college student’s unexplained injuries before his condition worsens. Meanwhile, after losing his most prized possession, Shaun’s distraction during a surgical procedure may end up risking more than just his job.

Shaun, Asher and Powell treat a young patient on Halloween with a rare hereditary disease, sending them down an uncharted path. Meanwhile, Glassman and Shaun must overcome their differences to work together to try and find a solution for Lim’s paralysis.