Sheldon attempts to build a nuclear reactor. Also, a university cocktail party gets heated when Dr. Sturgis’ colleague, Dr. Linkletter, flirts with Connie, and Georgie is heartbroken when he learns Veronica has a boyfriend.

Sheldon invites the entire school to a party for the Nobel Prize announcements. Also, Connie learns more about Dr. Sturgis' past, and Georgie's desire for cable TV leads to a standoff between him and George Sr.

Without Dr. Sturgis’ university class, Sheldon must find a new way to stay academically challenged. Also, Mary helps Pastor Jeff avoid temptation with his girlfriend.

Sheldon takes matters into his own hands when Connie refuses to drive him to a lecture with Dr. Linkletter. Also, Georgie tries to impress Veronica with his new business venture

Dr. Sturgis is furious when Sheldon accuses him of plagiarism. Also, Mary sets out to find a “girl trophy” for Missy’s end-of-season baseball ceremony, and Georgie has an awkward run-in with Veronica while on a date with his new girlfriend, Jana.

Sheldon's first day of college is derailed by his new philosophy teacher, Professor Ericson. Also, Mary and Brenda live vicariously through Missy's first day of middle school.

Connie takes matters into her own hands when Sheldon's philosophy teacher, Professor Ericson, sends him into a tailspin. Also, George Sr. learns Georgie has been cutting class.

Sheldon campaigns to become Dr. Linkletter's lab assistant. Also, Georgie enlists the help of Mr. Lundy, the drama teacher, for a surprising business venture.

Dr. Linkletter pushes Sheldon to make friends with his fellow students at college. Also, Georgie gets a pager.

Sheldon, Dr. Linkletter and Connie team up on a science experiment. Also, Mary is jealous that Pastor Jeff and Brenda are spending time together, and Georgie has a new side hustle.

Sheldon refuses to ride in a car after getting into an accident with Connie. Also, Missy uses their trauma to her advantage at school and Connie is forced to take the church shuttle while her car is in the shop.

Sheldon tries to convince Dr. Sturgis to return to the university. Also, Georgie upsets the family when he makes a life-changing decision.

Sheldon and Dr. Linkletter struggle to solve an equation. Also, Georgie has a solution for Connie's business woes, and George Sr. gives advice on Missy's love life.

Sheldon battles President Hagemeyer's mysterious boss over the university's science requirements. Also, Mary discovers that Georgie is working at Connie's illegal gambling room.

Sheldon gets the science yips and has to learn how to not think. Also, George Sr. plays handyman at Brenda Sparks' house.

Sheldon attends his first comic book convention; Mary tries selling makeup.

Sheldon butts heads with Dr. Lee, a new scientist in the lab. Also, Mary is given a lotto ticket.

Sheldon joins Dr. Linkletter and Dr. Sturgis on a science road trip. Also, Georgie continues to lie about his age.

Sheldon copes with the death of a hero. Also, Missy wants to babysit, and Georgie struggles with his big secret.

Sheldon and Missy learn about Georgie's pregnancy, and the whole family promises to keep it a secret.

Sheldon struggles to cope with the first signs of puberty. Also, Mary and George Sr. hunt for new jobs, and Georgie and Meemaw take a business trip across the border.

Sheldon and Missy try to help the family’s finances. Also, Mary struggles to find her footing without the church.

Sheldon makes a terrifying mathematical discovery while tutoring Billy. Also, Mary is jealous of Missy's relationship with Mandy and Connie.

Sheldon's search for a comic book leads him to a breakthrough. Also, Georgie and Mandy have an uncomfortable first encounter with her parents, Jim and Audrey.

Sheldon's database invention puts him at odds with the university. Also, the church takes issue with Connie's video store.

Sheldon learns the university is building a database without him. Also, Mary takes care of a bedridden Mandy and Meemaw.

Mary butts heads with Mandy's mother, Audrey, and Sheldon attempts male bonding.

Sheldon confronts the failure of his database. Also, Georgie and Mandy struggle as new parents and Missy feels forgotten.

Sheldon wants to search for life on other planets and Mandy answers Georgie's marriage proposal. Also, Missy is caught between two friends.

Mandy gets an exciting job opportunity and Sheldon worries that he's falling behind. Also, Georgie takes his daughter to work.

The gambling room gets broken into and Sheldon wants to study abroad. Also, Missy makes a new friend.

Mandy surprises Georgie with a spa weekend and Sheldon prepares for his summer in Germany.

Sheldon realizes he is the weakest student in his class; Meemaw is looking to expand her gambling business.

Georgie and Mandy get married! Meanwhile, Meemaw's gambling room gets raided.

Sheldon's published paper leads to a frenzy of grad school recruiting, and Georgie tries to speak more properly in front of his daughter.

George Sr. is worried that Mary wants another baby and gets a vasectomy behind her back. Meanwhile, Drs. Linkletter and Sturgis go to Sheldon for science tutoring.

The Cooper family grapples with the death of George Cooper Sr.