It's 2417, and the Planetary Union promotes Ed Mercer to Captain of the exploratory vessel The U.S.S. Orville. Ed's enthusiasm for his new position is dampened when his ex-wife, Kelly Grayson, is assigned to be his First Officer. While on their first routine mission, the Orville crew is ambushed by the Krill, a vicious alien race, who are bent on stealing a device that can cause time to accelerate.

The Orville is called to mediate a peace treaty between two warring cultures, but tensions run even higher between Ed and Kelly when a familiar face boards the ship. Meanwhile Yaphit declares his love for Dr. Finn with surprising results.

Kelly discovers that Lt. John Lamarr is smarter than he lets on. So, she pushes Ed to consider him for a key leadership position on the ship after The Orville gets damaged by a mysterious spatial anomaly causing harrowing effects to all things living.

Ed and the crew travel to Isaac's home planet, Kaylon.

The Kaylons take control of the Orville with the intention of destroying all biological lifeforms.

Ed discovers that Moclans aboard The Orville are harboring a secret.

The Orville explores a mysterious region of space.

The Orville crew makes a new discovery.

The Orville crew leads a Union delegation to sign a peace treaty with the Krill.

The Orville discovers a Kaylon with a very special ability.

The crew visit Haveena's sanctuary world and embark on a journey that may leave the Union more vulnerable.

The creation of a powerful new weapon puts the Orville crew — and the entire Union — in a political and ethical quandary.

A celebration is underway aboard the ship.