A young boy prostitute is butchered on the Williamsburg Bridge, alienist Laszlo Kreizler, newspaper illustrator John Moore, secretary Sara Howard & police commissioner Theodore Roosevelt investigate outside the law to find a serial killer.

Innovative evidence leads the team to discover a crucial element in the case is missing. Kreizler and Moore interview a witness to find out what happened to Moore at the Brothel. Sara attempts to live in a world outside the investigation. Kreizler challenges them to look within themselves.

Kreizler and Sara discuss the capacity to kill. Moore goes on a date. Byrnes and Captain Connor keep an eye on a potential suspect. Roosevelt finds himself under public scrutiny.

Kreizler and Moore follow a lead. Sara visits a hospital and is forced to confront her past. Cyrus, Kreizler’s carriage driver, recovers from his injuries. Byrnes and Connor plot against the team.