A young boy prostitute is butchered on the Williamsburg Bridge, alienist Laszlo Kreizler, newspaper illustrator John Moore, secretary Sara Howard & police commissioner Theodore Roosevelt investigate outside the law to find a serial killer.

Sara finds a clue and Kreizler tries to connect the evidence left behind by the serial killer. Kreizler takes Moore, Sara, Marcus and Lucius to Delmonico's in New York and informs them they're working together to catch the killer.

Kreizler mourns the loss of a friend. Sara pushes the team to forge ahead. Moore warns his friend the killer will strike again. Cyrus seeks revenge.