With Nic's due date steadily approaching, she and Conrad plan a relaxing day off, but their plans are interrupted when a patient with a medical mystery sends them rushing back to Chastain. Devon stays by Rose's side as she starts her clinical trial and things take a turn for the worse. Meanwhile, Kit is under pressure to bring Chastain out of debt.

On the day of Nic's baby shower, Billie takes full control to make sure it goes smoothly, but a secret she's been hiding changes everything. Devon and Leela stumble upon an apartment fire, where they assist in getting victims safely to Chastain and Leela gets a chance to prove her skills to Raptor. Jake and his husband deal with the complications of Sammie's health. Raptor and Rose receive exciting news.