Flight instructor Kelsey Berreth vanishes after she was last seen grocery shopping with her daughter on Thanksgiving in Woodland Park, CO; the case makes national headlines, but the secret behind Kelsey's disappearance is lurking much closer to home.

In Stephenville, TX, in 1987, Susan Woods doesn't show up for work for 2 days; she is discovered by her father dead at home in her bathtub. As police search for answers, they find a trail of victims - men associated with Susan, including her estranged husband living in Indianapolis. But the case wasn't solved for almost 2 decades.

Detectives in Washington, D.C., discover a puzzling connection between two women who disappeared two decades apart. An investigation reveals a sinister secret hidden along one of the busiest stretches of interstate in the country.

After Florida teacher Denise Hallowell is found murdered in her home, investigators examine her family's tumultuous past in their desperate search for a killer.