Ryan tags along to a disaster drill training at Station 19 where he and Jack get competitive. Captain Pruitt’s health weakens and Andy is sticking by his side. Meanwhile, both the firehouse crew and police department respond to a strip mall fire, forcing Jack and Ryan to work together.

When Station 19 gets called to a structure fire at a coffee processing plant, the team risks their lives to save Station 42’s captain. Meanwhile, Ripley and Vic consider a shocking option to save their relationship; Andy gets some surprising news about some of her fellow crew members, and Pruitt takes on a new position.

Following a life-threatening situation that left the future of a member of Station 19 unclear, the crew gathers to face the outcome. Andy and Ben respond to a man impaled by a chandelier. Meanwhile, Station 19 is called upon to organize shipments of supplies and assist with wildfires in Los Angeles.

After a car crashes into Joe’s Bar, Andy and Sullivan lead the team of firefighters as they work to rescue their fellow crewmates Ben and Pruitt, Grey Sloan doctors and interns, and bar patrons before the building comes crumbling down.

The crossover continues on Grey's Anatomy S16E10 Help Me Through the Night (II).

Ben, Jackson and Emmett are put in a precarious and dangerous position with a potential victim. Andy’s search for more background on her family opens her eyes, and Vic and Travis are caught in the middle of a corruption scheme.

Andy, Sullivan, Dean and Ben are faced with a tough choice while trying to save a couple trapped in their car. Meanwhile, Dean second guesses his legal fight against the Seattle Police Department; Travis’ dad fears he will be outed when his “golfing friend” is exposed to COVID-19; and Carina’s immigration status is called into question.