Investigators embark on a 15 year hunt for the killer of a Wisconsin pharmacist.

A hunting safari in Zambia ends in a nightmare when a shot rings out from inside the campground.

After an apparent brazen home invasion during the holiday season in a quiet Connecticut community leaves Connie Dabate dead, investigators discover a silent witness that cracks the case wide open.

Nearly 40 years after a young wife and mother is found murdered in her upstate New York home, a new team of investigators joins the cold case to uncover the killer. Andrea Canning reports.

Updates in the murder case of former NBA star Lorenzen Wright are revealed.

When a Texas D.A. and his wife are killed two months after a prosecutor’s murder in the same town, law enforcement fears they may be in the sights of a serial killer. Andrea Canning reports.

Following her husband's sudden death, a Utah mother-of-three writes a book to help her children through their grief; when investigators learn the cause of death and dig deeper into their lives, she is charged with murder.

The investigation into the poisoning death of Wisconsin mother-of-two Julie Jensen takes a surprising turn when detectives learn that Julie wrote a letter just days before her death pointing to a possible suspect.

An investigation into the murders of several women found dead along Gilgo Beach in Long Island, N.Y.

After Tahereh Ghassemi disappears from the Louisiana home she shares with her adult son, detectives discover that she'd recently come into a great deal of money; the investigation reveals an astonishing plot with international implications.

When 17-year-old Alissa Turney is reported missing in Phoenix, it takes years before detectives treat her case as a homicide; a new investigation unearths dark family secrets.

While responding to a house fire in New Jersey, firefighters discover the burned remains of homeowner Rob Cantor in the basement, leading investigators to question what really happened: new interviews and legal developments about the latest twists and turns in the case.

A mother searches for answers in the unsolved murder of her 14-year-old daughter until new DNA technology changes everything.

When deadly gunfire erupts in an Austin, Texas, home in the middle of the night, detectives wonder if the homeowners' jewelry business is a possible motive; an investigation uncovers a suspect that no one saw coming.

Navy petty officer and devoted mother Sherri Malarik is found shot to death in her minivan after she disappeared. The case remains cold until new revelations and old memories resurface, dividing the Florida family.

A mystery looms over a small New York town when a woman is murdered and a stunning secret is exposed; more than a decade later, new developments lead to an unexpected conclusion.

Twenty-seven-year-old Egypt Covington is found murdered in her home; investigators in Michigan quickly identify a person of interest but years pass without an arrest.

A woman goes missing and investigators uncover her husband's chilling history including dark secrets about another missing wife.

Two women are murdered in the same Arlington, Texas apartment complex, and police are stumped. Years later, evidence from two subsequent rapes provides a breakthrough. Andrea Canning reports.

A young Fairfield, Ohio, woman, 21-year-old Katelyn Markham, vanishes one summer night in 2011, prompting her community to conduct a massive search. When her skeletal remains are found in Indiana two years later, investigators question her friends and family to uncover her killer, but it takes 12 years and a detective with dogged determination.

A monster storm had rolled into Canton, Massachusetts, and Karen Read's boyfriend, police officer John O'Keefe, was dead, his body discovered in front of another officer's house. Karen was charged with John's death. Was she to blame?

In Marietta, Georgia, a woman's murder shines a light on an unsolved mystery from years earlier. As the connection between the two cases becomes clear, a long-hidden truth surfaces. Could a master manipulator be behind both crimes? Andrea Canning reports.

Dubbed the 'Black Swan' case, a former ballerina falls in love with a man 30 years her senior, but when their love story spirals out of control, one of them winds up dead.

Millionaire entrepreneur Lance Herndon is found bludgeoned to death in his Atlanta home. The search for his killer reveals no shortage of suspects or secrets.

Andrea Canning reports on the dramatic updates in the case of international fugitive Nicholas Rossi who faked his death as law enforcement closed in on him for alleged crimes of rape and fraud; will the man with multiple identities finally face justice?

The high-profile case of two murdered Indiana teens takes a stunning turn after video of the killer, taken by one of his victims shortly before their deaths, is revealed.

Kaitlyn Conley was convicted of manslaughter in 2017 after the death of Mary Yoder by poison. Conley maintains she is innocent and continues her fight to overturn the conviction.

Mike Sisco and his fiancé Karen Harkness are found shot to death in their Topeka duplex in 2002. A years-long search for the killer and three criminal trials over two decades reveals strained dynamics within one victim’s family.

A West Virginia pharmacist is left widowed after her husband, 38-year-old Michael Cochran, suddenly dies. Their close-knit neighborhood rallies around the family until troubling details emerge regarding the couple's new business venture.