When the urn goes missing, Alaric, Hope, Josie, Lizzie, Kaleb, Dorian and Emma hit the road to locate the artifact before the next Malivore creature arrives. Meanwhile, Lizzie takes aim at Hope for all the past spring breaks she’s ruined. Finally, the group bands together when a town-wide quarantine threatens to expose their supernatural identities.

Hope becomes more determined than ever to find her way back to Mystic Falls. Alaric continues looking into the mysterious night Malivore was destroyed. As the students leave for summer vacation, Landon stays behind to keep an eye on Rafael.