Let me become a great red blood cell one day... This is the story of Red Blood Cell before she became Red Blood Cell, when she was a young Erythroblast. The Erythroblasts are training hard to become full-fledged Red Blood Cells under the supervision of their teacher, Macrophage. But Erythroblast is directionally-challenged, and she’s always getting lost in the middle of drills. One day, while practicing to evacuate from bacteria, Erythroblast once again loses her way...

Red Blood Cell has been assigned to train a rookie Red Blood Cell! She resolves to “show her what a dependable senpai I am!” But she keeps losing her way, and getting yelled at by other cells, so it’s not going very smoothly. Just then, a major incident rocks the world inside the body.

A mysterious cell wearing a stylish hat appears before the regular cells, who are bored with just the same (cell division) work repeatedly, every day. This mysterious cell lures the regular cells into a mischievous scheme against White Blood Cell and Killer T Cell. The regular cells enjoy working out their everyday, pent-up frustration. But just who exactly is this cell wearing a stylish hat?