London, 1899. Three years after an inexplicable event suddenly equips them with extraordinary abilities, Amalia True and Penance Adair work to protect their kind from widespread, deepening antipathy. Meanwhile, police inspector Frank Mundi investigates a string of murders at the hands of a reportedly Touched and highly dangerous serial killer named Maladie.

Penance creates an amplifier to spread Mary's hope-inspiring song across the city – but first, Mary must find her elusive voice. As danger mounts against her group, Amalia propositions an unlikely ally and sets out to expand the Orphanage's reach. Swann further entangles Augie and Mundi in his business affairs.