Ben and Tom make a germ that goes big and he makes friends to be friends with them. Everyone but Ben anyways.

Jeremy the Germ is back. Using Talking Ben to do his germy dirty work, Jeremy sits back to watch the zombie germ apocalypse spread through the neighborhood. But Talking Tom and the gang aren't going down without a fight. Will they cure everyone before it's too late?

Because of a glitch in Talking Ben's computer, monsters from the video game world are pouring into town and turning everyone into piles of pixels. Talking Tom and Talking Ben race to save the world as their friends fall one by one to the invading horde. In order to fix this, they'll have to turn to some of their greatest enemies. But will even that be enough?