The Whiskey team is sent to Prague for their first official mission where Will has to seduce the widow of a notorious shipping tycoon in order to gain access to a list of criminal clients, but Frankie doubts his ability to deceive a grieving woman. Back in New York, the bureau assigns the team a new liaison, who just so happens to be the last person Will wants to see.

Will and Frankie continue to clash, and their growing pains may jeopardize the team's next mission in Rome where they are sent to prevent a terrorist attack.