To fix Hyakkimaru's broken sword, he and Dororo travel to a village where a master swordmaker named Munetsuna lives. Upon arriving at Munetsuna's house, they are met by his daughter Okowa.

Inside Daigo's castle, Lady Nui appears before the cell in which Dororo has been imprisoned. Meanwhile, Hyakkimaru is also approaching the castle as he tries to take back both his body and Dororo. Behind Hyakkimaru stands Midoro, who has transformed into a ghoul.

Daigo's castle is engulfed in flames. Within, two brothers by blood are at the mercy of fate. Dororo, Jukai and Lady Nui also head for the castle, each with their own thoughts weighing down upon their hearts. For a life that began with a silenced cry, where will the path of destiny lead?