After receiving a cryptic, urgent distress call from Dr. Beverly Crusher, Admiral Jean-Luc Picard enlists help from generations old and new to embark on one final adventure: a daring mission that will change Starfleet, and his old crew forever.

Aided by Seven of Nine and the crew of the U.S.S. Titan, Picard makes a shocking discovery that will alter his life forever – and puts him on a collision course with the most cunning enemy he’s ever encountered. Meanwhile, Raffi races to track a catastrophic weapon – and collides with a familiar ally.

Caught by Starfleet and facing court martial, paranoia grows as Picard struggles to uncover whether a prodigal crewman from his past has returned as an ally – or an enemy hellbent on destroying them all.

Now on the run, Picard and the skeleton crew of the U.S.S. Titan must break into Starfleet's most top-secret facility to expose a plot that could destroy the Federation. Picard must turn to the only soul in the galaxy who can help: an old friend.

A devastating revelation about Jack alters the course of Picard’s life forever – and uncovers a truth that threatens every soul in the Federation. The final battle begins as Picard and his crew race to save the galaxy from annihilation – but not without a gut-wrenching cost.

In a desperate last stand, Jean-Luc Picard and generations of crews both old and new fight together to save the galaxy from the greatest threat they’ve ever faced.