After a mass casualty event wipes out every creature with a Y chromosome, President Jennifer Brown responds to the crisis. Yorick fears he may be the only survivor. Hero attempts to right a wrong.

With Jennifer and Yorick reunited, Agent 355 pitches a plan for what comes next. The dead President's daughter, Kimberly, circles Jennifer's secret. Meanwhile, Nora Brady and her daughter Mack say goodbye to home.

Yorick and Agent 355 search for Dr. Allison Mann in war-torn Boston. Back in D.C., Jennifer hides the truth about Yorick from her political rivals.

Kimberly uncovers a secret. 355 and Allison reach an understanding. Yorick stumbles upon a mysterious town where things are not what they seem.

As tensions at the Pentagon come to a head, Jennifer faces a threat. The Amazons hit the road.