One fateful day, high school sprinter Hitomi Kanzaki experiences a disturbing vision of another world and discovers from her best friend that Amano (the track team star she has a crush on) is about to go abroad. On an impulse, she asks him the next day for her first kiss -- if she can sprint 100 meters in thirteen seconds. But then, a young warrior prince and a dragon appears before Hitomi during the run ....

In a shaft of light, Hitomi and the prince Van tranports to the world of Gaea, where Earth is known only as the "Mystic Moon" in the nightly expanse. Van returns to the capital of his country Fanelia to be coronated after obtaining the Energist crystal from the dragon. During the coronation rite, the Zaibach empire launches an invasion with Guymelef Alseides mecha, and Van must retrieve at his mentor Balgus's bidding Escaflowne, the legendary god of protection of Fanelia.

With her upcoming marriage to Dryden on her mind, Millerna ask omi for a tarot reading on its outcome. Hitomi reads a prediction of misfortune and disaster, but decides to tell Millerna a prediction of happy fortune instead. She hopes her thoughts and faith alone would be enough to change fate and reverse the prediction. Her hope is shattered by the entrance of fortune-enhanced soldiers Naria and Eriya at the wedding.

When Hitomi asked to get away from this world of fighting, she found herself transported back to Earth. It is once again the day before Hitomi would make her fateful confession to Amano and thus encounter Van. Reliving the events would reunite her with Van, but at the risk of hurting her best friend Yukari and returning back to the war.

At long last, Dornkirk's vision of reviving the power of Atlantis seems realized as the Sphere of Absolute Fortune's effects spread across the battlefield and the world of Gaea. However, the war does not end as the Destiny-Altering Device only turns the combatants' bellicose thoughts into reality. Gaea's fate in the end lies in a girl from the Mystic Moon and a white-winged dragon.