Tired of Jameson giving Spider-Man the rap for all the crime in New York, Peter decides to give up the superhero business once and for all, until he meets his biggest fan, a little girl named Tyina. Can she get Spidey to change his mind?

Spider-Man loses his memory and becomes partners in crime with Dr. Octopus. Can a little girl and a cabbie save him?

Worried that Kingpin is going to eliminate him after the botched framing of Peter Parker, Alistair Smythe arranges a meeting with Spider-Man to give him information about Kingpin. However, when Spidey arrives, he discovers Smythe has been turned into a cyborg. Part man, part machine, he is now the ultimate spider-slayer! However, when his programming malfunctions, he goes after the man he feels responsible for his father's death...Norman Osborn! Peter must fight a crazed Smythe, as well as his feelings when he discovers Mary Jane, the woman he loves, and Harry, his best friend, are engaged!

Robbie Robertson is losing his son, Randy, to a gang of thugs lead by Tombstone. When this harder-than-stone hit man tries to use his history with Robbie to kill a story about his new boss, Alicia Silvermane, he runs afoul of Spider-Man. Both discover Robbie's bond with his child and his ethical resolve is mightier.

Under the psychiatric care of Dr. Kafka, Eddie Brock has come to believe that Venom is a figment of his imagination. Then Baron Mordo tempts Eddie -- reunification with the alien symbote that makes him as powerful as Venom.

Spider-Man and Venom must put aside their differences and help Iron Man stop Carnage and Baron Mordo from releasing Dormammu.

Peter Parker and Mary Jane are finally a couple, but there happiness is short-lived as the Green Goblin, armed with a time distorter and the true identity of Spider-Man, seeks to destroy Spidey, by any means necessary.

Peter is shocked by MJ's new powers so they seek Curt Conners' help in figuring everything out. MJ tells them about a dream she's been having, which may be a clue to her disappearance. But Hydro-Man finds them and kidnaps MJ again. Will Spidey be able to find her by following the clues from her dream?

Spider-Man is transported to an alien world, where he meets the Beyonder, a being who wants to see if good is stronger then evil. He then summons a group of the greatest villains from Earth to this world and tells Spider-Man to put together a group of heroes to fight them, and save the planet.

Spider-Man finds himself in yet another dimension, where he meets .... himself!

Spider-Man is sent through several dimensions trying to fix time and seal away Spider-Carnage. Peter meets his would be girlfriend Gwen Stacey and Stan Lee.